@charset "utf-8";

:root{
  --color-cimzia: #ed9200;
  --color-text-cimzia: #277842;
  --ucbcblack: #222222;
  --ucbcblack80: rgba( 34, 34, 34, 0.8);
  --ucbcbase: #FAF5F5;
  --ucbcgray: #666666;
  --ucbcgraylight: #DDDDDD;
  --ucbcgraypale: #F6F6F6;
  --ucbcwhite: #FFFFFF;
  --ucbcwhite80: rgba(255, 255, 255, 0.8);
  --ucbckey: #F18070;
  --ucbckeyv: #CD5D19;
  --ucbckeye: #D81125;
  --ucbckeypale: #F8F4FA;
  --g1: #A75ED8;
  --g2: #6988E4;
  --g3: #33AFF0;
  --ge1: #D81125;
  --ge2: #DF3E4E;
  --ge3: #F0A8AF;
  --mgaccent: #F26F21;
  --mg: #ED9B33;
  --mgbg: #FFFcf5; 
}

body.prod-cimzia * {
  --brandcolor: var(--color-cimzia);
  --brandtextcolor: var(--color-text-cimzia); 
}

body {
  font-size: 16px;	
  line-height: 1.6em;
}
.secBrandTop .logo > img {
  width: 80%;
}

.note {
  font-size: 1.4rem !important;
  line-height: 1.6em !important;
  margin-top: 0.8em;
}
.note.wide-mt {
  margin-top: 1.6em;
}
.note.wide-mb {
  margin-bottom: 1.6em;
}
.align-center {
  text-align: center;
}
.align-right {
  text-align: right;
}

.mt-0 {
  margin-top: 0 !important;
}
.mt-3_2rem {
  margin-top: 3.2rem !important;
}
.mt-4_0rem {
  margin-top: 4.8rem !important;
}


/* ---------- css fix? ---------- */
#wrap {
  min-width: auto;
}
.secBrandAnchor {
  padding-top: 18px;
  padding-bottom: 17px;  
}
.secBrandAnchor .linkList {
  flex-wrap: wrap;
  align-items: stretch;
}
.secBrandAnchor .linkList .item {
  margin: 6px 0;
  border: none;
  margin-left: -1px;
  background-color: var(--brandcolor);
  display: flex;
  align-items: center;
  box-sizing: border-box;
  text-align: center;
}
.secBrandAnchor .linkList .item + .item {
  border-left: none;
}
.secBrandAnchor .linkList .item::before,
.secBrandAnchor .linkList .item::after {
  content: '';
  display: inline-block;
  width: 1px;
  height: 100%;
  background-color: #fff;
}
@media screen and (max-width: 768.98px){
  .secBrandAnchor .linkList {
    margin: 0;
  }
  .secBrandAnchor .linkList .item:nth-child(3n + 1) {
    border-left: none;
  }	
}

@media screen and (max-width: 768.98px){
  .secBrandTop .logo {
    height: auto;
	width: 300px;
	max-width: 70%;
  }
  .secBrandCts .pmd-secTtl {
     font-size: 2.6rem;	  
  }
}

a.brand-color-link,
a.brand-color-link > span {
  color: var(--brandtextcolor);
  font-weight: bold;
}
a.brand-color-link > span {
  text-decoration: underline;
}
a.itemInr {
  transition: opacity 0.3s ease-in-out;
}
a.itemInr:hover {
  opacity: 0.7;
}

.bg-brandColor,
.secTtl::after {
  background-color: var(--brandcolor) !important;	
}




/*-- Headline --*/
#contents-main .index-container section > h2 {
  font-size: 2.5rem;
  font-weight: bold;
  line-height: 1.2em;
  padding-bottom: 0.8rem;
  color: var(--brandtextcolor);	
}
#contents-main .product-section > h2 {
  font-size: 2.1rem;
  font-weight: bold;
  line-height: 1;
  color: var(--brandtextcolor);
  background: #ff7200;
  background: linear-gradient(to right, rgba(219, 238, 202, 100) 50%, rgba(219, 238, 202, 0));
  padding: 1.6rem;
  border-radius: 8px;
  margin-bottom: 1.6rem;
}
@media screen and (min-width: 769px) {
	.product-section > h2:not(.visually-hidden) ~ * {
	  margin-left: 2.0rem;
	}
}
#contents-main .product-section > section > h3 {
  font-size: 1.9rem;
  margin-bottom: 1.0rem;
  border-left: 5px solid var(--brandtextcolor);
  padding: 0.4rem 0 0.4rem 0.5rem;
  color: var(--brandtextcolor);
}

/*
#contents-main section h3 {
  font-size: 2.0rem;
  font-weight: bold;
  line-height: 1.2em;
  padding-bottom: 0.8rem;
  color: var(--brandtextcolor) !important;	
}
#contents-main .product-section h3 {
  font-size: 2.0rem;
  font-weight: bold;
  line-height: 1;
  display: flex;
  align-items: flex-start;
  padding-bottom: 0;
}
#contents-main .product-section h3::before {
  content: '';
  display: block;
  width: 1.8rem;
  aspect-ratio: 1 / 1;
  margin-top: 0.2rem;
  margin-right: 0.5rem;
  border-top-left-radius: 20%;
  border-bottom-right-radius: 20%;
  flex-shrink: 0;
  flex-grow: 0;
}
#contents-main section > h3 {
    font-size: 2.5rem;
}
.product-section h2 {
  font-size: 3.0rem;
  font-weight: bold;
  padding-bottom: 0.8rem;
}
*/





#contents-main section:not(.check-item) {
  padding-top: 1.6rem;
  padding-bottom: 4.8rem;
}
#contents-main section > section:not(.check-item) {
  padding-bottom: 1.6rem;
}
#contents-main section > section:not(.check-item):last-of-type {
  padding-bottom: 0;
}
#contents-main section p {
  font-size: 1.6rem;
  line-height: 1.6em;
}



.one-column-container,
.two-column-container,
.three-column-container {
  display: grid;
  column-gap: 3.2rem;
  grid-auto-rows: 1fr;
  align-items: start;
  row-gap: 3.2rem;
}
.one-column-container {
  grid-template-columns: 100%;
}
.two-column-container {
  grid-template-columns: repeat(2, 1fr);
}
.three-column-container {
  grid-template-columns: repeat(3, 1fr);
}

@media screen and (max-width: 768.98px) {
  .two-column-container {
    grid-template-columns: 100%;
    align-items: center;
  }	
}

.column-container li {
  border-radius: 8px;
  height: 100%;
  overflow: hidden;
}

.column-container li a {
  padding: 1.6rem;
  height: 100%;
  box-sizing: border-box;
}


#block-certificate-number-cimzia {
  background-color: #f7f5f8;
  padding: 0 0 1.0rem 0;
}
#block-certificate-number-cimzia .certificate-number {
  text-align: right;
  font-size: 1.1rem;
}

@media screen and (max-width: 768.98px) {
  #block-certificate-number-cimzia {
    padding-left: 20px;
    padding-right: 20px;	
  }
}
nav.buttons li {
  border: 1px solid #859595;
  background-color: #fff;
  text-align: center;
}
nav.buttons li a {
  display: flex;
  justify-content: space-between;
  font-size: 2.0rem;
  font-weight: bold;
  text-decoration: none;
  padding: 25px 25px 24px;
  line-height: 1.45;
}
@media screen and (max-width: 768.98px) {
  nav.buttons li a {
    font-size: 1.8rem;
  }
}
#contents-main .buttons {
  margin-top: 6.4rem;
}
.buttons.content-ring {
  margin-top: 3.2rem;
}
nav.buttons.content-ring li a {
  font-size: 1.6rem;
  padding: 15px 25px 14px;
}

.with-left-arrow,
.with-right-arrow {
  display: flex;
  align-items: center;
  position: relative;
}
.with-right-arrow::after,
.with-left-arrow::before {
  content: '';
  display: block;
  width: 1.5em;
  aspect-ratio: 29 / 7;
  background: url("/sites/default/files/2025-03/icn_arow_s_cimzia.svg") no-repeat center center;
  transition: all 0.3s ease-in-out;
}
.with-left-arrow::before {
  transform: scale(-1, 1);
}

.material-link-cover:hover ~ * {
  opacity: 0.7;
}

.material-link-cover:hover ~ div .with-left-arrow::before,
.with-left-arrow:hover::before {
  margin-left: -10px;
  padding-right: 10px;
}

a:hover + .with-right-arrow::after,
#link-to-autoclicks-movie > a:hover + div .with-right-arrow::after, 
#link-to-pdf-wrapper .pdf-item > a:hover + div .with-right-arrow::after, 
.material-link-cover:hover ~ div .with-right-arrow::after,
.with-right-arrow:hover::after {
  margin-right: -10px;
  padding-left: 10px;
}
nav.buttons li.link-prev a {
  justify-content: flex-start;
  text-align: left;
}
nav.buttons li.link-next a {
  justify-content: flex-end;
  text-align: right;
}



/* ---------- internal-links ---------- */
/*20230803*/
nav.internal-links {
  padding: 3.2rem 0 4.8rem 0;	
}
nav.internal-links ul {
  background-color: #fff;
}
nav.internal-links li {
  display: inline-flex;
  position: relative;
  align-items: flex-start;
}
nav.internal-links li a {
  display: inline-block;
  font-size: 1.6rem;
  text-decoration: none;
}
nav.internal-links li::before {
  content: '';
  display: block;
  width: 0.8rem;
  height: 0.8rem;
  border-top: 2.0px solid var(--brandcolor);
  border-right: 2.0px solid var(--brandcolor);
  transform: rotate(135deg);
  margin-top: 0.5rem;
  margin-right: 0.5rem;
}
nav.internal-links li:not(:last-of-type) {
  margin-right: 3.2rem;	
}
@media screen and (min-width: 769px){
  nav.internal-links ul {
    display: block;
    padding: 19px 25px 18px;
    border: 1px solid #859595;
    border-radius: 8px;
  }
  nav.internal-links li {
    font-weight: bold;
	margin: 6px 0;
  }
}
@media screen and (max-width: 768.98px){  
  nav.internal-links ul {
    display: flex;
	flex-direction: column;
	padding-top: 3.2rem;
    padding-bottom: 3.2rem;
	border-top: 1px solid #ddd;
	border-bottom: 1px solid #ddd;
	margin-left: -20px;
	margin-right: -20px;
	padding-left: 20px;
    padding-right: 20px;
  }
  nav.internal-links ul > li:not(:first-of-type) {
    margin-top: 3.2rem;  
  }
}
.internal-links + .lead {
  margin: 1.6rem 0 3.2rem;
}



/* ---------- internal-links ---------- */
.reference {
  margin-top: 4.8rem;
}
.reference dl {
  display: grid;
  grid-template-columns: max-content auto;
  row-gap: 0.3em;
  align-items: start;
}
.reference dd,
.reference dt {
  font-size: 1.3rem;
  color: #444;
  line-height: 1.4em;
}
.reference dt {
  justify-self: end;
}
.reference dt::after {
  content: "\0FF09"; /* ） */
}


@media screen and (max-width: 768.98px) {
  body {
    -ms-overflow-style: none;
    scrollbar-width: none;
  }
  body::-webkit-scrollbar {
    display: none;
  }
}

#contents-main section .section-body > section:not(:last-of-type) {
  padding-bottom: 3.2rem;
}
#contents-main section .section-body > section:last-of-type {
  padding-bottom: 0;
}

@media screen and (min-width: 769px) {
 .spOnly {
    display: none;
 }
}
@media screen and (max-width: 768.98px) {
 .pcOnly {
    display: none;
 }
}
.iblock {
  display: inline-block;
}

.right {
	text-align: right;
}

.col2 {
    grid-column: 1 / 3;
}

p {
  line-height: 1.6em;
}
/*
dl.with-colon dt::after {
  content: "\0FF1A";
  display: inline-block;
}
.note dl.with-colon.no-margin-right dt {
  margin-right: 0;
}
*/
sup.reg {
  display: inline-block;
  font-size: 2.2rem;
  font-weight: normal;
  line-height: 0;
  vertical-align: middle;
  top: -50%;
}

#contents-main .product-section > p + p {
  margin-top: 1.6rem;
}



figure {
  padding-top: 2.4rem;
}
figcaption {
  font-size: 1.7rem;
  font-weight: bold;
  line-height: 2.7rem;
  display: flex;
  align-items: flex-start;
  margin-bottom: 0.8rem;
}

figcaption::before {
  content: '';
  display: block;
  width: 1.8rem;
  aspect-ratio: 1 / 1;
  margin-top: 0.6rem;
  margin-right: 0.5rem;
  border-radius: 20%;
  flex-shrink: 0;
  flex-grow: 0;
  background: var(--brandcolor);
}

div.lead {
  padding-top: 2.4rem;
}
div.lead p {
  font-size: 1.6rem;
  line-height: 1.6em;
}

.scrollable-element-wrapper {
  overflow: scroll;
  position: relative;
  -ms-overflow-style: none;
  scrollbar-width: none;
}
.scrollable-table-wrapper {
  max-height: 60vh;
}
.scrollable-element-wrapper::-webkit-scrollbar {
  display: none;
}
.scrollable-element-wrapper table {
  min-width: 100%;
}
.scrollable-element-wrapper tr.spOnly > th > span {
  display: inline-block;
  position: sticky;
  left: 0.6rem;
  max-width: calc(100vw - 40px - 1.2rem);
}


.basic-table {
  border-collapse: separate;
  border: none;
  width: 100%;
}
.basic-table th,
.basic-table td {
  border: 1px solid #000;
  border-left: none;
  border-top: none;
  font-size: 1.45rem;
  line-height: 1.4em;
  padding: 0.3rem 0.6rem;
  white-space: nowrap;
}
.side-effect-table tbody th {
  white-space: wrap;
  min-width:150px;
}
.basic-table thead > tr:first-of-type > * {
  border-top: 1px solid #000;
}
.basic-table tr > *:first-child:not(.not-left-edge) {
  border-left: 1px solid #000;
}


.basic-table th {
  vertical-align: middle;
}
.basic-table thead th {
  text-align: center;
  background-color: #96be89;
}
.basic-table tbody th {
  text-align: left;
  background-color: #fff;
}
.basic-table tbody .grouping > * {
	background-color: #ccdcc9;
}
.basic-table tbody .grouping > th {
	text-align: left;
}
.basic-table tbody .grouping ~ tr:not(.grouping) th {
	padding-left: 2.0rem;
}
.basic-table td {
  text-align: center;
  vertical-align: middle;
  background-color: #fff;
}
.basic-table .size-control {
  display: inline-block;
  text-align: inherit;
}
@media screen and (max-width: 768.98px) {
  .basic-table tbody tr:not(.spOnly) th {
    font-weight: normal;
	padding-left: 1.6rem;
  }
}
.scrollable-element-wrapper th,
.scrollable-element-wrapper thead td {
  position: sticky;
}
.scrollable-element-wrapper thead td {
  z-index: 400;
}
.scrollable-element-wrapper thead th {
  z-index: 300;
}
.scrollable-element-wrapper tbody th {
  z-index: 290;
}
.scrollable-element-wrapper tbody td {
  z-index: 100;
}

.product-table th.group-header {
  padding-top: 1.0em;
  padding-bottom: 1.0rem;
}
.product-table tbody th {
  text-align: left;
}
.side-effect-table thead > tr:first-of-type > th:first-of-type {
	position: sticky;
	top: 0;
	left: 0;
	z-index: 500;
}





.figcaption-wrapper {
  display: flex;
  justify-content: space-between;
  align-items: flex-end;
  margin-bottom: 1.0rem;
}
.figcaption-wrapper figcaption {
  margin-bottom: 0;	
}
#contents-main section .figcaption-wrapper p {
  font-size: 1.4rem;
  padding: 0.3rem 1.6rem;
  border-radius: 2.4rem;
  flex-shrink: 0; 
  margin-left: 1.6rem;
  color: #fff;
}
.figcaption-wrapper p.pe {
  background-color: #1d4389;
}
.figcaption-wrapper p.se {
  background-color: #858ab8;
}
.figcaption-wrapper p.other {
  background-color: #6e6e70;
}


.product-section .section-body figure + p {
	margin-top: 2.4rem;
}

#efficacy.product-section .section-body p + p {
	margin-top: 1.6rem;
}


.reference.inline-reference {
  margin-top: 0.8rem;	
  text-align: right;
}
/*
.product-section h2 + .reference.inline-reference {
  margin-bottom: 3.2rem;	
}
*/
.reference.inline-reference dl {
  display: inline-grid;
  text-align: left;
}
.reference.inline-reference p {
  font-size: 1.3rem !important;
  line-height: 1.4em !important;  
}
.section-body h4 {	margin-top: 0;
	margin-bottom: 2.4rem;
}

.pi-container p {
	font-size: 1.6rem;
	margin-bottom: 0;
}
.pi-container h4 {
	margin-bottom: 0;
}
.pi-wrapper {
	border: 1px solid #000;
	padding: 1.6rem;
	background-color: #FFF;
}
.pi-wrapper-Contraindications,
.pi-wrapper-warning {
  border-color: #FF0000;
}
.pi-wrapper-warning * {
  color: #FF0000;
}
.pi-wrapper + .pi-wrapper {
  margin-top: 1.6rem;
}
.pi-wrapper > .primary-item:not(:first-of-type) {
  margin-top: 3.2rem;
}
p + .pi-wrapper {
  margin-top: 0.8rem;
}
.pi-wrapper dl {
	margin-top: 1.0rem;
	display: grid;
	grid-template-columns: max-content minmax( 0, 1fr );
	row-gap: 1.0rem;
}
.pi-wrapper dl > * {
	font-size: 1.6rem;
	line-height: 1.5em;
}
.pi-wrapper dl.primary-item > dt,
.pi-wrapper dl.primary-item > dd > h4 {
	font-size: 1.8rem;
}
.pi-wrapper dt {
	font-weight: bold;
	margin-right: 0.5rem;
}
.pi-wrapper > p {
  margin-top: 1.0rem; 
}

#contents-main .product-section .pi-container .pi-wrapper *:not(sup) {
	font-size: 1.6rem;
	color: #000;
	line-height: 1.6em;
}
.pi-container .pi-wrapper .basic-table {
	width: auto;
	margin: 0.8rem 0;
}
.pi-container .pi-wrapper .basic-table thead th {
	background: none;
}
.pi-container .pi-wrapper .basic-table th {
	font-weight: normal;
}
.pi-container .pi-wrapper .basic-table tbody tr > * {
	padding-left: 1.6rem;
	padding-right: 1.6rem;
}
.pi-container .pi-wrapper .basic-table tbody th {
	text-align: center;
}
div.japanese {
	margin: 2.4rem 0 0.8rem 0;
	padding: 0.5rem 1.0rem;
	font-size: 1.7rem;
	font-weight: bold;
	background-color: #ffd88f;
	width: fit-content;
}
.video-section,
.video-section * {
  box-sizing: border-box;
}
.video-section iframe {
  margin-top: 3.2rem;
  aspect-ratio: 16 / 9;
  width: 100%;
}
.video-section h4 + iframe {
	margin-top: 1.6rem;
}
.index-container {
  padding-top: 0;
}
.internal-links + .index-container {
	padding-top: 2.4rem;
}

#contents-main .index-container section .buttons {
	margin-top: 3.2rem;
	margin-bottom: 2.4rem;
}

#block-page-title {
	padding-bottom: 3.2rem;
}

#block-page-title + #block-main-page-content #contents-main {
    padding-top: 0;
}

dd figure {
	padding-top: 1.6rem;
}

dd > figure:first-child {
  padding-top: 0;
  margin-top: -0.8rem;
}

.attention-wrapper {
  padding-top: 3.2rem;
}
.attention {
  margin-bottom: 1.6rem;
  padding: 0.8rem;
  font-size: 1.6rem;
  border: 1px solid #000;
  font-weight: bold;
}
.lined-box {
  padding: 1.0em;
  border-top-left-radius: 1.6rem;
  border-bottom-right-radius: 1.6rem;
  background-color: #fff;
  border: 1px solid var(--ucbcgraylight);
  height: fit-content;	
  box-sizing: border-box;
}
.p-separeted p + p {
  margin-top: 1.6em;
}
.column-container.contents-container > figure {
  width: 100%;
}

#contents-main .internal-links + .section.product-section {
	padding-top: 0;
}
#contents-main .internal-links + .section.product-section .lead {
	padding-top: 1.6rem;
	padding-bottom: 3.2rem;
}
ol.with-number {
  counter-reset:num;
}

#contents-main ol.with-number > li {
  padding-top: 2.4rem;
}
#contents-main ol.with-number > li:first-of-type {
  padding-top: 1.4rem;
}
#contents-main ol.with-number section {
  padding: 0;	
  width: 100%;
}

#contents-main ol.with-number *:not(sup) {
  font-size: 1.6rem;
  line-height: 1.6em;
}

@media screen and (min-width: 769px){
  ol.with-number > li {
    display: flex;
    justify-content: flex-start;
    align-items: flex-start;
  }
  ol.with-number > li::before {
    counter-increment: num;
    content: counter(num) ".";
    justify-self: flex-end;
    font-weight: bold;
    margin-right: 0.3rem;
  }
}
@media screen and (max-width: 768.98px){
  ol.with-number > li h5::before {
	display: inline-block;
    counter-increment: num;
    content: counter(num) ".";
    font-weight: bold;
    margin-right: 0.3rem;
  }
}
ol.with-number > li h5 {
  padding-bottom: 0.8rem;
}

#necessities {
  margin: 0.5rem 0;
}


ul.with-circle > li,
ul.with-disc > li {
  display: flex;
  align-items: flex-start;
  justify-content: flex-start;
}  
ul.with-circle > li::before {
  content: "\02022";
  margin: 0 0.5em;
}
ul.with-disc > li::before {
  content: "\025CF";
  margin: 0.5rem 0 0.2em;
}


a.material-link {
  display: flex;
  font-size: 1.6rem;
  font-weight: bold;
  text-decoration: none;
  padding: 0;
  line-height: 1.45;
  text-align: center;
  margin-top: 1.6rem;
  margin-right: 1.6rem;
  color: var(--brandtextcolor);
  width: fit-content;
  margin-left: auto;
}
a.material-link > span {
  transition: opacity 0.3s ease-in-out;
  display: block;
  padding: 16px 16px 15px;
  border-left: 16px solid var(--brandcolor);
  text-align: left;
}
a.material-link:hover > span {
  opacity: 0.7;
}


.bg-brandColor .linkList .disabled {
  color: #999999;
  cursor: default;
}
.bg-brandColor .linkList .disabled:hover,
.bg-brandColor .linkList a[href=''] {
  opacity: 1;
}

.normal-weight {
  font-weight: normal;
  color: #000;
  font-size: 1.6rem;
}

p.pi-link {
    margin: 1.0rem 0 0 0;
    text-align: right;
}
.index-container nav li a.with-right-arrow {
    text-align: left;
}







.buttons a.locked--content > span, 
.buttons span.locked--content {
	display: flex;
}

.index-container .buttons .locked--content > span::before, 
.buttons .link-prev span.locked--content::after,
.buttons .link-next span.locked--content::before, 
.locked--content + .with-right-arrow-locked::before {
    content: "";
    content: '';
    align-self: center;
    font-size: inherit;
    display: inline-block;
    width: 1.2em;
    height: 1.2em;
    background-image: url(/sites/default/files/2023-09/mg.password.svg);
    background-position: center;
    background-size: contain;
    background-repeat: no-repeat;
	flex-grow: 0;
	flex-shrink: 0;
}
.buttons .link-prev span.locked--content::after {
	margin-left: 0.38em;
}
.index-container .buttons .locked--content > span::before,
.buttons .link-next span.locked--content::before, 
.locked--content + .with-right-arrow-locked::before {
	margin-right: 0.38em;
}


.img-bg {
  background-color: #fff;
  border-radius: 8px;
  padding: 1.6em;
  margin-top: 3.2rem;
  border: 1px solid #f0c372;
}
.visually-hidden + .img-bg {
  margin-top: 0;
}
.img-wrapper {
  display: block;
  justify-content: center;
  position:relative;
  margin-left: auto;
  margin-right: auto;
}
.img-wrapper img {
  display: block;
  margin: 0 auto;
}
.image-size-note {
  margin-top: 1.6rem;
  margin-left: auto;
  margin-right: auto;
}
.side-effect-table caption.note {
  text-align:right;
  caption-side: bottom;
}
.scrollable-element-wrapper + .scrollable-element-wrapper {
  margin-top: 3.2rem;
}
.grid-list {
  display: grid;
  grid-template-columns: max-content auto;
  column-gap: 0.4em;
}
.grid-list.no-gap {
  column-gap: 0;
}
.pi-explanation {
  row-gap: 1.0rem;
  margin-top: 1.0rem;
}
.flex-list {
  list-style:none;
}
.flex-list > li {
  display: flex;
  align-items: start;
}
.flex-list > li:not(:first-child) {
  margin-top: 0.8em;
}
.list-style-disc li::before {
  content: "\025CF";
  padding: 0 0.4em;
  color: #63a767;
}
p + .list-style-disc,
.list-style-disc + p {
	margin-top: 1.6rem;
}

.list-style-triangle li::before {
  content: "\025B6";
  font-size: 0.7em;
  padding: 0 0.4em;
  color: #63a767;
}
#ra-injection-site-container {
  display: grid;
  max-width: 900px;
  width: 100%;
  grid-template-columns: repeat(3, 1fr);
  column-gap: 5%;
  row-gap: 0;
  margin: 0 auto;
}
#ra-injection-site-container img {
	display: block;
	margin: 0 15px;
	width: calc(100% - 30px);
}
@media screen and (min-width: 769px){
	#ra-injection-site-container p:nth-of-type(1) {
		grid-column: 1 / 3;
	}

}
@media screen and (max-width: 768.98px){
	#ra-injection-site-container {
	  display: grid;
	  width: 100%;
	  grid-template-columns: 100%;
	  column-gap: 0;
	  row-gap: 0;
	}	
	#ra-injection-site-container img {
		max-width: 250px;
		margin: 0 auto;
	}
	#ra-injection-site-container p {
		margin: 1.5rem 0 0 0;
	}
	#ra-injection-site-container img:nth-of-type(1) {
		grid-row: 1;
	}
	#ra-injection-site-container img:nth-of-type(2) {
		margin-top: 1.5rem;
		grid-row: 2;
	}
	#ra-injection-site-container p:nth-of-type(1) {
		grid-row: 3;
	}
	#ra-injection-site-container img:nth-of-type(3) {
		grid-row: 4;
		margin-top: 2.5rem;
	}
	#ra-injection-site-container p:nth-of-type(2) {
		grid-row: 5;
	}
}

.goodgrips {
  margin-top: 1.6rem;
  display: grid;
  grid-template-columns: 100%;
}
.goodgrips img {
  justify-self: end;
  width: 200px;
}


#copayment-container > div {
  display: grid;
  background: #dbeeca;
  border-radius: 8px;
  padding: 3.2rem;
}
#copayment-container > div > p {
  text-align: center;
  color: #277842;
  font-weight: bold;
}

.download-button {
  border: 1px solid #f39800;
  background: #f9de9c;
  display: block;
  text-align: center;
  text-decoration: none;
  padding: 0.5em;
  border-radius: 8px;
  font-weight: bold;
  color: #444;
  margin-top: 1.6rem;
}
.download-button:hover {
  opacity: 0.6;
}
.download-button span {
  display: flex;
  align-items: center;
  justify-content: center;
  line-height: 1.0em;
}
.download-button span::before {
  content: '';
  display: block;
  background-image: url("/sites/default/files/2025-03/icon_pdf.png");
  background-repeat: no-repeat;
  background-size: contain;
  width: 35px;
  margin-right: 0.5em;
  aspect-ratio: 4 / 5;
  min-height: 30px;
  border: 0;
}

#require-caution dt {
  font-weight: bold;
  color: var(--brandcolor);
  padding-bottom: 0.5rem;
}
#require-caution dt::before {
  content: "\025A0";
}
#require-caution dd:not(:last-child) {
  padding-bottom: 1.0rem;
}
section.check-item {
  background-color: #f8fcf5;
  border-radius: 8px;
  border: 1px solid #48a070;
  padding: 2.4rem;
  margin-top: 1.6rem;
}
strong.coloring {
  color: #f00;
}
.check-item-inner {
  display: grid;
  grid-template-columns: auto max-content;
  align-items: center;
  padding: 1.6rem;
  border-radius: 8px;
  column-gap: 1.6rem;
  background-color: #fff;
}
.check-item-warning-wrap {
  max-height: 0;
  overflow: hidden;
  transition: 0.2s;
}
.check-item-warning {
  margin-top: 1.6rem;
  background: #f8c7ca;
  padding: 1rem;
  border-radius: 8px;
  color: #e12b15;
  font-weight: bold;
}
.check-item .item-wrap {
  margin-left: -3.0rem;
  align-items: center;
}
.check-item .item-wrap h5 {
  display: grid;
  grid-template-columns: max-content auto;
  font-size: 1.7rem;
  line-height: 1.4em;
  align-items: center;
}
.check-item .item-wrap h5.with-note {
  margin-top: -8px;
}
.check-item .item-wrap h5::before {
  content: "項目";
  display: flex;
  align-items: center;
  justify-content: center;
  white-space: nowrap;
  font-size: 1.4rem;
  height: 4.0rem;
  width: 4.0rem;
  font-weight: normal;
  border-radius: 50%;
  background: radial-gradient(at 30% 30%, #fbd597, #d43f14, #e3490d);
  box-shadow: 2px 2px 4px rgba(0, 0, 0, 0.3);
  text-shadow: 1px 1px 2px rgba(0, 0, 0, 0.3);
  color: #fff;
  margin-right: 1.0rem;
}
.check-item .item-wrap dl{
  margin: -0.6rem 0 0 5.0rem;
}

.check-item .check-container {
  display: flex;
}  
.check-item .check-container li {
  border-radius: 0.5rem;
  box-shadow: inset 0 2px 0 rgba(255, 255, 255, 0.2), inset 0 -2px 0 rgba(0, 0, 0, 0.05);
  min-width: 150px;
  margin-left: 1.6rem;
}
.check-item .check-container-wide li {
  min-width: 200px;
}
.check-item label{
  height: 4.0rem;
  position: relative;
  padding: 1.0rem 0.5rem;
  display: flex;
  justify-content: center;
  align-items: center;
}

.check-item label > span {
  position: relative;
  text-decoration: none;
  color: #fff;
  text-shadow: 0 0 5px rgba(0, 0, 0, 0.7);
  font-weight: bold;
  font-size: 1.6rem;
  line-height: 1.6rem;
  text-align: left;
  display: block; 
  margin-left: 2.1rem;
  align-items: center;
}
.check-item label > span::before {
  content: "";
  position: absolute;
  left: -2.1rem;
  display: block;
  width: 1.6rem;
  height: 1.6rem;
  background: #fff;
  border: 1px solid rgba(0, 0, 0, 0.5);
  border-radius: 0.25rem;
  margin-right: 0.5rem;
}
.check-item label:has(:checked) > span::after {
  content: "";
  position: absolute;
  width: 1.8rem;
  height: 0.9rem;
  border-bottom: 3px solid #f00;
  border-left: 3px solid #f00;
  top: -0.2rem;
  left: -2.1rem;
  transform: rotate(-45deg);
}

.check-item .check-ok {
  background-image: linear-gradient(to bottom, #cbd8c7 0%, #62a563 49%, #299449 52%, #00450b 100%);
  border: solid 2px #12652f;
}
.check-item .check-ng {
  background-image: linear-gradient(to bottom, #f6d6b5 0%, #f18a2b 49%, #ed6c00 52%, #e33a0f 100%);
  border: solid 2px #df7a31;
}
.check-item .check-ok:has(:checked) {
  background-image: linear-gradient(to bottom, #cddee8 0%, #51abd0 49%, #0d96c3 52%, #004766 100%);
  border: solid 2px #00698f;
}
.check-item .check-ng:has(:checked) {
  background-image: linear-gradient(to bottom, #eed5dc 0%, #e495ae 49%, #d7387b 52%, #8c134a 100%);
  border: solid 2px #b03e6b;
}
.check-item:has(.check-ng input:checked) .check-item-warning-wrap {
  max-height: 30rem;
}
.check-container li:has(.label-container) {
  display: flex;
  justify-content: center;
  align-items: stretch;
}
.check-container li .label-container {
  align-self: center;
}
.label-container label {
  padding: 0;
  height: fit-content;
  width: 100%;
  flex-grow: 10;
}
.label-container label span {
  line-height: 1.6rem;
}
.label-container-row {
  display: grid;
  grid-template-columns: 100%;
  justify-content: center;
  row-gap: 0.8rem;
}
.label-container-col {
  display: grid;
  grid-template-columns: max-content max-content;
  column-gap: 1.0rem;
  justify-self: center;
}
.check-container label .with-triangle {
  display: flex;
  align-items: center;
}
.check-container label .with-triangle .triangle {
  font-size: 0.7em;
  padding: 0 0.2rem;
}

@media screen and (max-width: 768.98px){
  .check-item-inner {
    grid-template-columns: 100%;
  }
  .check-container {
	margin-top: 1.6rem;
  }
  .check-container li {
    flex-basis: 50%;
  }
}
@media screen and (max-width: 599.98px){ 
  .check-item .check-container {
    display: grid;
	grid-template-columns: 100%;
	grid-auto-rows: 1fr;
	row-gap: 1.6rem;
  }
}



.material-list {
  display: grid;
  column-gap: 3.2rem;
  align-items: start;
  row-gap: 3.2rem;
  grid-template-columns: repeat(3, 1fr);
  margin-top: 3.2rem;
  grid-auto-rows: max-content;  
}
.material-list.one-column-container {
  grid-template-columns: 1fr;	
}
.material-list > li {
  list-style: none;
  text-align: center;
  margin: 0 0 1rem;
  border: 2px solid #6a9a73;
  border-radius: 8px;
  height: 100%;
  display: grid;
  grid-template-columns: 100%;
  grid-auto-rows: max-content max-content auto;
  background-color: #fff;
  position: relative;
}
.material-list > li > * {
	z-index: 80;
}
.material-list > li > a {
	position: absolute;
	top: 0;
	left: 0;
	width: 100%;
	height: 100%;
	z-index: 100;
}
.material-list > li .with-right-arrow {
	font-weight: bold;
	color: #ed9200;
	justify-self: end;
	align-self: end;
	height: fit-content;
	margin-right: 1.6rem;
	margin-bottom: 1.6rem;
}
.material-list li.starter-kit {
  grid-column: 1 / 3;
  grid-row: 1 / 2;
}
.material-list .material-link-cover {
  background-color: transparent;
  position: absolute;
  width: 100%;
  height: 100%;
  top: 0;
  left: 0;
  z-index: 999;
}
.material-list picture {
  width: 200px;
  aspect-ratio: 243	/ 340;
  display: flex;
  align-items: center;
  justify-content: center;
  margin: 1.6rem;
  justify-self: center;
}
.material-list .landscape picture {
  width: 280px;
  height: 280px;
}
.material-list img {
  max-width:100%;
  max-height: 100%;
  filter: drop-shadow(2px 2px 4px rgba(0, 0, 0, 0.3));
}
.material-list li.starter-kit picture {
  width: auto;
  aspect-ratio: auto;
}
.material-list h5 {
  margin: 1.6rem 1.6rem 0 1.6rem;
  padding: 0.8rem;
  background: linear-gradient(to bottom, #0f8b4f, #044e1d);
  border-radius: 8px;
  font-weight: bold;
  color: #fff;
  font-size: 1.8rem;
  line-height: 2.2rem;
  min-height: 6.0rem;
  display: flex;
  justify-content: center;
  align-items: center;
  box-shadow: 2px 2px 4px rgba(0, 0, 0, 0.3);
}
.material-list p {
  display: flex;
  justify-content: center;
  text-align: left;
  padding: 0 1.6rem;
}
.material-list .starter-kit p {
  display: block;
}
.material-list .starter-kit-materials {
  background-color: #f8fcf5;
  border-radius: 8px;
  margin: 1.6rem 1.6rem 0 1.6rem;
  padding: 1.6rem;
  text-align: left;
}
.material-list .starter-kit-materials dt {
  font-weight: bold;
  color: var(--color-text-cimzia);
}

.material-list .starter-kit-materials dd ul li::before {
  content: "\02022";
  margin-right: 0.5rem;
  margin-left: 1.6rem;
}
.material-list .starter-kit-materials dd ul li {
	display: inline-block;
}
#procedure-wrap dt,
#procedure-wrap dd {
  margin-top: 0.8rem;
}
#procedure-wrap dt {
  font-weight: bold;
  color: #63a767;
}
h3.visually-hidden + .lead {
  padding-top: 0.8rem;
}
.no-shadow {
  filter: none !important;
}
@media screen and (max-width: 1079.98px){
  .material-list {
    grid-template-columns: repeat(2, 1fr);
  }
}
@media screen and (max-width: 768.98px){
  .material-list {
    grid-template-columns: 1fr;
  }
  .material-list li.starter-kit {
    grid-column: 1 / 2;
  }
  .material-list {
    grid-auto-rows: unset;  
  }
  .material-list picture {
    aspect-ratio: auto;
	margin: 3.2rem 0;
  }
  .material-list .landscape picture {
    height: auto;
  }

}



/*-- Top Visual --*/

#cimzia-ra-top-visual img {
	max-width: 100%;
	border: 1px solid #aaa;
}
#cimzia-ra-top-visual + p {
	margin-top: 1.6rem;
	
}


#contents-main section#link-to-autoclicks-movie {
	border: 1px solid #00621f;
    background-color: #fff;
    text-align: center;
	border-radius: 8px;
	padding: 1.6rem;
	position: relative;
	margin-bottom:1.6rem;
}
#contents-main section#link-to-autoclicks-movie > a,
#link-to-pdf-wrapper .pdf-item > a {
	position: absolute;
	top: 0;
	left: 0;
	width: 100%;
	height: 100%;
}
#link-to-autoclicks-movie-inner {
	display: grid;
	grid-template-columns: 200px max-content;
	margin: 0 auto;
	column-gap: 50px;
	align-items: center;
	width: fit-content;
}


#link-to-autoclicks-movie-inner h2 p {
	text-align: left;
	color: #00621f;
	font-size: 2.2rem;
}
#link-to-autoclicks-movie-inner h2 p:not(:first-child) {
	color: #859595;
}
#link-to-autoclicks-movie-inner img {
	width: 100%;
	grid-row: 1;
	grid-column: 1;
}
@media screen and (max-width: 768.98px) {
	#link-to-autoclicks-movie-inner {
		grid-template-columns: 1fr;
		width: auto;
	}
	#link-to-autoclicks-movie-inner div {
		grid-row: 1;
		grid-column: 1;
	}
	#link-to-autoclicks-movie-inner img {
		width: 100%;
		grid-row: 2;
		grid-column: 1;
		max-width: 200px;
		justify-self: end;
	}	
}
#link-to-autoclicks-movie-inner .with-right-arrow,
#link-to-pdf-wrapper .pdf-item .with-right-arrow {
	margin-top: 1.5rem;
	color: #ed9200;
	font-weight: bold;
}
#link-to-pdf-wrapper {
	display: grid;
	grid-template-columns: repeat(2, 1fr);
	column-gap: 1.6rem;
}
#link-to-pdf-wrapper .pdf-item {
	border: 2px solid #ed9200;
    background-color: #faf5ec;
    text-align: center;
	border-radius: 8px;
	padding: 1.6rem;
	position: relative;
}
#link-to-pdf-wrapper .pdf-item > div {
    max-width: 350px;
    margin: 0 auto;
}
#link-to-pdf-wrapper .pdf-item h3 {
	display: flex;
	font-size: 1.8rem;
	line-height: 2.5rem;
	text-align: left;
}
#link-to-pdf-wrapper .pdf-item h3::before {
	content: '';
	display: block;
	height:5.0rem;
	aspect-ratio: 4 / 5;
	margin-right: 1.0rem;
	background-image: url("/sites/default/files/2025-03/icon_pdf.png");
	background-repeat: no-repeat;
	background-size: contain;
	background-position: top;
	flex-shrink:0;
	flex-grow: 0;
}

@media screen and (max-width: 999.98px) and (min-width: 769px){ 
	#link-to-pdf-wrapper .pdf-item h3 {
		flex-direction: column;
	}
	#link-to-pdf-wrapper .pdf-item h3::before {
		margin-right: 0;
		margin-bottom: 0.5rem;
	}
	#link-to-pdf-wrapper .pdf-item h3 > span {
		text-align: center;
	}
}
@media screen and (max-width: 768.98px) {
	#link-to-pdf-wrapper {
		grid-template-columns: 1fr;
		grid-auto-rows: 1fr;
		row-gap: 1.6rem;
	}
}
#link-to-pdf-wrapper .pdf-item > div {
	display: flex;
	flex-direction: column;
	justify-content: space-between;
	height: 100%;
}
#link-to-pdf-wrapper .pdf-item.announce-item {
	border-color: #00621f;
	background-color: #f8fcf5;
}
#link-to-pdf-wrapper .pdf-item .with-right-arrow {
	justify-content: end;
}

#ra-dosing-schedule-image img {
	width: 1000px;
}

.with-image-text {
	display: flex;
	flex-direction: column;
	width: fit-content;
	margin: 0 auto;
}
.with-image-text::after {
	content: 'イメージ図';
	display: block;
	font-size: 1.3rem;
	text-align: right;
	margin: -0.8rem 1.6rem 0 0;
}

#steps-to-start-self-injection {
	width: 460px;
}

.cmz_prd .secBrandTop .indicationList li.item a {
	background-color: #fff;
	border: 1px solid #336633;
}
#block-ucbcarejp-content > article[about='/product/cimzia/content'] li.item:has(.ra-item) {
	display: none;
}
#block-ucbcarejp-content > article[about^='/product/cimzia/content/rheumatoid_arthritis'] li.item:has(.cimzia-item) {
	display: none;
}